I am working on different browsers from last few months. As per my experience I have seen there is lobby in browsers. Most of the browsers are having same platform. Like
Mozilla
Netscape
Flock
Omniweb
3B
Camino
These all browsers are built on the same platform (Internet Explorer):
All IE versions
AOL
So as per my experience if you covered all four (IE, Firefox, Opera & Safari) browsers then you have most probably covered all browsers (not talking about mobile etc browsers).
But yes browser issues are depends on the operating system also :)